Based on years of experience in the world's leading applications in aperture and atomic force microscopy in nano life sciences, JPK of Germany has built these two technologies on the same inverted optical microscope for the first time, launching the world's first commercial aperture-atomic force microscope OT -AFM. OT-AFM not only has the surface imaging and force measurement functions of AFM, but also has the highest sensitivity 3D force measurement performance of the diaphragm system.
The collection of three-dimensional high-precision mechanical measurement and control and AFM high-resolution imaging will open up a whole new field of application. This combined system not only meets the most stringent mechanical stability requirements, but also has a very high sensitivity and modular design. The uniquely designed combination platform is the key to integrating JPK diaphragms with AFM and cell force spectrometers in research-grade inverted microscopes. JPK has very mature and high-end advanced optics in hardware and software (such as TIRF,
Confocal, STED, etc.) combined with technical experience, we can easily correlate advanced optical data with optical and AFM data. In dynamic experiments, JPK
AFM is acquired synchronously with optical data without interfering with each other, so this combined system can provide more dimensional operating space in mechanical measurements.
The combined system OT-AFM can be applied to many new research areas, including: intracellular interactions; cell-to-cell or cell-matrix interactions; immune responses; bacterial/viral infections and nanoparticle uptake. JPK's renowned light and AFM technology, combined with fluorescence technology, set the highest standard in living cell research.
JPK Chief Technology Officer (CTO) Torsten
Dr. Jahnke describes this exciting breakthrough: “Functional particles or modified microbes trigger cell reactions are common methods. AFM-based methods can also observe changes in cell structure, kinetics, and mechanical properties, but target Transport to the cell's characteristic area is still very difficult to achieve. The light can accurately manipulate cells or trigger cellular responses in time and space, which can significantly improve the productivity, repeatability and flexibility of these studies. Our unique OT The -AFM system has been used to quantitatively study the effect of signaling between dendritic cells (DCs) and beta-regulated T cells (Treg) on ​​the performance of general T cells (Tconv) adhering to the same dendritic cells."
About JPK
JPK in 1999
Founded in Berlin, Germany, it is a global leader in high-tech nano-analytical instruments. Its products include high-resolution high-resolution fast atomic force microscopy, fully automatic force spectrometer, force-measuring diaphragm, and cell force spectrometer. High-precision analytical instruments are widely used in high-tech research fields such as life sciences, polymers, and nanomaterials. JPK established “Jiekeke Precision Instrument Trade (Shanghai) Co., Ltd.†in China in 2014, and established analytical laboratories, consumable spare parts warehouses and after-sales service centers to provide efficient and perfect testing solutions for Chinese users. After-sales service and comprehensive technical support.
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